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En ny studie visar att SGLT2-hämmaren empagliflozin även förbättrar prognosen för patienter med hjärtsvikt och bevarad vänsterkammarfunktion.

En patientgrupp där det tidigare har saknats framgångsrik behandling.

Det här är det inom alla kategorier största som hände på årets ESC-kongress, menar Lars Lund, överläkare vid hjärtkliniken, Karolinska Universitetssjukhuset som bevakade området.

Läs hela rapporten från årets europeiska kardiologi konferens ESC på www

https://www.netdoktorpro.se/kardiologi/artiklar/esc-2021-hjartsviktsstudie-far-stor-uppmarksamhet-under-arets-mote-kongress-esc-2021/?utm_campaign=ND_21_09_PRO_Nyhetsbrev_20&utm_medium=email&utm_source=Eloqua

Här finnes aktuell artikel pdf hela studien free

https://www.nejm.org/doi/full/10.1056/NEJMoa2107038?query=featured_home

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

Abstract

BACKGROUND

Sodium–glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain.

METHODS

In this double-blind trial, we randomly assigned 5988 patients with class II–IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once daily) or placebo, in addition to usual therapy. The primary outcome was a composite of cardiovascular death or hospitalization for heart failure.

RESULTS

Over a median of 26.2 months, a primary outcome event occurred in 415 of 2997 patients (13.8%) in the empagliflozin group and in 511 of 2991 patients (17.1%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.69 to 0.90; P<0.001). This effect was mainly related to a lower risk of hospitalization for heart failure in the empagliflozin group. The effects of empagliflozin appeared consistent in patients with or without diabetes. The total number of hospitalizations for heart failure was lower in the empagliflozin group than in the placebo group (407 with empagliflozin and 541 with placebo; hazard ratio, 0.73; 95% CI, 0.61 to 0.88; P<0.001). Uncomplicated genital and urinary tract infections and hypotension were reported more frequently with empagliflozin.

CONCLUSIONS

Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes. (Funded by Boehringer Ingelheim and Eli Lilly; EMPEROR-Preserved ClinicalTrials.gov number, NCT03057951


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