S U M M A R Y

Metformin, a medication used to lower glucose levels in patients with diabetes mellitus, has long been thought to increase the risk for a
metabolic disorder known as lactic acidosis. This review summarised data from all known comparative and observational studies lasting at least one month, and found no cases of fatal or nonfatal lactic acidosis in 70,490 patient-years of metformin use, or in 55,451 patientyears
for those not on metformin. Average lactate levels measured during metformin treatment were no different than for placebo or for other medications used to treat diabetes.

In summary, there is no evidence at present that metformin is associated with an increased
risk for lactic acidosis when prescribed under the study conditions.

Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2010, Issue 4

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